Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

• DOI: 10.1016/j.heliyon.2024.e28351
• Publication Date: 2024-03-21T00:35:39Z
• Authors: Claudia Cerracchio; Luca Del Sorbo; Francesco Serra; Alessia Staropoli; Maria Grazia Amoroso; Francesco Vinale; Filomena Fiorito
• Keywords: Pyrone; Coronavirus; Pandemic; 2019-20 coronavirus outbreak

Canine coronavirus (CCoV) can produce a self-limited enteric disease in dogs but, because of notable biological plasticity coronaviruses (CoVs), numerous mutations as well recombination events happen leading to the emergence variants often more dangerous for both animals and humans. Indeed, new canine-feline recombinant alphacoronaviruses, recently isolated from humans, highlight cross-species transmission potential CoVs. Consequently, effective antiviral agents are required treat CoV infections. Among candidates development drugs against CoVs infection, fungal secondary metabolites (SMs) represent an important source investigate. Herein, ability 6-pentyl-α-pyrone (6 PP), SM obtained by