Efferocytosis: Current status and future prospects in the treatment of autoimmune diseases

• DOI: 10.1016/j.heliyon.2024.e28399
• Publication Date: 2024-03-31T14:10:11Z
• Authors: Qianwei Li; Huan Liu; Geng Yin; Qibing Xie
• Keywords: efferocytosis; Immunotoxicology; Immunopharmacology

Billions of apoptotic cells are swiftly removed from the human body daily. This clearance process is regulated by efferocytosis, an active anti-inflammatory during which phagocytes engulf and remove cells. However, impaired associated with development various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease. In this review, we conducted a comprehensive search relevant studies published January 1, 2000, to present, focusing on disease pathogenesis, regulatory mechanisms governing potential treatments targeting process. Our review highlights key molecules involved in different stages efferocytosis-namely, "find me," "eat "engulf digest" phases-while elucidating their relevance pathology. Furthermore, explore therapeutic modulating efferocytosis restore immune homeostasis mitigate responses. By providing theoretical underpinnings for treatment contributes advancement strategies field.