Distinct roles of CD244 expression in cancer diagnosis and prognosis: A pan-cancer analysis

• DOI: 10.1016/j.heliyon.2024.e28928
• Publication Date: 2024-03-30T07:15:56Z
• Authors: Zhenzhen Deng; Yuanhong Liu; Haiyan Zhou
• Keywords: Immunotherapy target; H1-99; 0303 health sciences; Science (General); Pan-cancer; Biomarker; Prognosis; Immune infiltration; Social sciences (General); Q1-390; 03 medical and health sciences; CD244; Research Article

The abnormal expression of tumor associated genes in pan-cancer is closely related to the clinicopathological features distinct cancer types. Thus, identifying role specific needed for developing effective anti-cancer strategies. However, function CD244 has not been fully understood. In this study, we explored profile across 33 types based on Cancer Genome Atlas project, Gene Expression Omnibus database, and other bioinformatics tools. We found down-regulated levels seven up-regulated two subsequently relationship between survival rate expression, positive patients with adrenocortical carcinoma (ACC), head neck squamous cell (HNSC), skin cutaneous melanoma (SKCM), uterine corpus endometrial (UCEC). further investigated association tumor-infiltrating immune cells, discovered their correlation different tumors. that level was higher normal samples than UCEC samples, positively CD8+ T cells infiltrating. mutation status, promoter methylation, CD244-related molecules signaling pathways were also employed study potential initiation progression. Our offers a comprehensive overview human tumors, revealing as prognostic biomarker immunotherapeutic target cancers.