Non-targeted effects of radiation therapy for glioblastoma

• DOI: 10.1016/j.heliyon.2024.e30813
• Publication Date: 2024-05-09T07:37:21Z
• Authors: Lucie Lerouge; Aurélie Ruch; Julien Pierson; Noémie Thomas; Muriel Barberi-Heyob
• Keywords: Abscopal effect; Bystander effect; Narrative review

Radiotherapy is recommended for the treatment of brain tumors such as glioblastoma (GBM) and metastases. Various curative palliative scenarios suggest improved local-regional control. Although underlying mechanisms are not yet clear, additional therapeutic effects have been described, including proximity abscopal reactions at site. Clinical preclinical data that immune system plays an essential role in regulating non-targeted radiotherapy GBM. This article reviews current biological caused by external internal radiotherapy, how they might be applied a clinical context. Optimization regimens requires assessment complexity host on activity immunosuppressive or immunostimulatory cells, glioma-associated macrophages microglia. also discusses recent models adapted to post-radiotherapy responses.This narrative review explores status responses both locally via "bystander effect" remotely "abscopal effect". Preclinical observations demonstrate unirradiated near far from irradiation site, can control tumor response. Nevertheless, previous studies do address problem its global context, present gaps regarding link between different types fractionation schemes synthesis scientific literature should help update critique available medical knowledge. Indirectly, it will formulate new research projects based interpretation results non-systematic selection published studies.