Liraglutide ameliorates TAC-induced cardiac hypertrophy and heart failure by upregulating expression level of ANP expression

H1-99 0301 basic medicine Science (General) Heart failure Apoptosis Liraglutide Social sciences (General) Cardiac hypertrophy Q1-390 03 medical and health sciences ER stress ANP Research Article
DOI: 10.1016/j.heliyon.2024.e32229 Publication Date: 2024-05-31T11:51:18Z
ABSTRACT
Recent studies have underscored the cardioprotective properties of liraglutide. This research explores its impact on cardiac hypertrophy and heart failure following transverse aortic constriction (TAC). We found that liraglutide administration markedly ameliorated cardiac hypertrophy, fibrosis, and function. These benefits correlated with increased ANP expression and reduced activity in the calcineurin A/NFATc3 signaling pathway. Moreover, liraglutide mitigated ER stress and cardiomyocyte apoptosis, and enhanced autophagy. Notably, the positive effects of liraglutide diminished when co-administered with A71915, an ANP inhibitor, suggesting that ANP upregulation is critical to its cardioprotective mechanism.
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