Liraglutide ameliorates TAC-induced cardiac hypertrophy and heart failure by upregulating expression level of ANP expression
H1-99
0301 basic medicine
Science (General)
Heart failure
Apoptosis
Liraglutide
Social sciences (General)
Cardiac hypertrophy
Q1-390
03 medical and health sciences
ER stress
ANP
Research Article
DOI:
10.1016/j.heliyon.2024.e32229
Publication Date:
2024-05-31T11:51:18Z
AUTHORS (8)
ABSTRACT
Recent studies have underscored the cardioprotective properties of liraglutide. This research explores its impact on cardiac hypertrophy and heart failure following transverse aortic constriction (TAC). We found that liraglutide administration markedly ameliorated cardiac hypertrophy, fibrosis, and function. These benefits correlated with increased ANP expression and reduced activity in the calcineurin A/NFATc3 signaling pathway. Moreover, liraglutide mitigated ER stress and cardiomyocyte apoptosis, and enhanced autophagy. Notably, the positive effects of liraglutide diminished when co-administered with A71915, an ANP inhibitor, suggesting that ANP upregulation is critical to its cardioprotective mechanism.
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CITATIONS (2)
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