Characterization of carbapenemase-producing Enterobacterales from rectal swabs of patients in the intensive care units of a tertiary hospital in Cali-Colombia

• DOI: 10.1016/j.heliyon.2024.e33368
• Publication Date: 2024-06-21T07:03:18Z
• Authors: Mónica Fernandes-...; Ernesto Martínez-...; José H. Bravo; Lorena Matta-Cortés; Johann A. Ospina-...; Claudia C. Parede...
• Keywords: Social sciences (General); H1-99; 0301 basic medicine; Klebsiella pneumoniae; Q1-390; 03 medical and health sciences; Science (General); Antibiotic resistance; Carbapenemase-producing Enterobacterales; Carbapenem-resistant; Research Article

Carbapenemase-producing Enterobacterales (CPE) represents a significant threat to global health. This study aimed to characterize clinically and molecularly the CPE isolated from rectal swabs of patients in the intensive care units (ICUs) of a tertiary hospital in Cali, Colombia.This was a cross-sectional observational study. Rectal swabs from patients admitted to the ICUs were collected. Bacterial identification and carbapenemase production were determined using phenotypic and molecular methods. Demographic and clinical data were extracted from electronic medical records.The study included 223 patients. Thirty-six patients (36/223, 16.14 %) were found to be colonized or infected by CPE. Factors such as prolonged stay in the ICU, previous exposure to carbapenem antibiotics, use of invasive procedures, and admission due to trauma were associated with CPE. Klebsiella pneumoniae (52.5 %) was the most prevalent microorganism, and the dominant carbapenemases identified were KPC (57.8 %) and NDM (37.8 %).Distinguishing carbapenemase subtypes can provide crucial insights for controlling dissemination in ICUs in Cali, Colombia.