Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinoma

• DOI: 10.1016/j.heliyon.2024.e33554
• Publication Date: 2024-06-25T00:28:34Z
• Authors: Weiyu Kong; Jiaxin He; Qinyao Zhou; Xin Zhou; Xiyi Wei; Yonglin Yang; Yiwen Mei; Shuai Wang; Xi Zhang; Bing Yao; Yulin Yue; Jiali Xu; Minjun Jiang; Chen Xu
• Keywords: Histone lactylation; TIMP1; Social sciences (General); H1-99; 0301 basic medicine; Tumour microenvironment; Q1-390; 03 medical and health sciences; Science (General); Cancer-associated fibroblasts; Research Article

Recent research emphasised the indispensable role of histone lactylation in activation hepatic stellate cells. The VHL mutation is extremely common clear cell renal carcinoma, which normally causes a metabolic shift cancer cells and increases lactate production, eventually creating lactate-enriched tumour microenvironment. Cancer-associated fibroblasts (CAFs) promote progression, also vital carcinoma. Therefore, this study investigated CAFs its impact on patient survival. Multiomics technology was employed to determine lactylation-related genes evolution correlated with function molecular signatures CAFs. results suggested that TIMP1 hub gene