Upregulation of LncRNA UCA1 promotes cardiomyocyte proliferation by inhibiting the miR-128/SUZ12/P27 pathway

• DOI: 10.1016/j.heliyon.2024.e34181
• Publication Date: 2024-07-05T02:16:17Z
• Authors: Kang Huang; Denggao Huang; Qiang Li; Jianghua Zhong; Yilei Zhou; Zanrui Zhong; Shilin Tang; Wei Zhang; Zibin Chen; Shijuan Lu
• Keywords: Social sciences (General); H1-99; Q1-390; 0303 health sciences; 03 medical and health sciences; lncRNA UCA1; Science (General); Cardiomyocyte proliferation; P27; miR-128; suz12; Research Article

Enhancing cardiomyocyte proliferation is essential to reverse or slow down the heart failure progression in many cardiovascular diseases such as myocardial infarction (MI). Long non-coding RNAs (lncRNAs) have been reported regulate proliferation. In particular, lncRNA urothelial carcinoma-associated 1 (lncUCA1) played multiple roles regulating cell cycle and diseases, making lncUCA1 a potential target for promoting However, role of remains unknown. This study aimed at exploring function underlying molecular mechanism Quantitative RT-PCR showed that expression decreased postnatal hearts. Gain-and-loss-of-function experiments positively regulated