The TWIK-related acid sensitive potassium 3 (TASK-3) channel contributes to the different effects of anesthetics on the growth and metastasis of ovarian cancer cells

• DOI: 10.1016/j.heliyon.2024.e34973
• Publication Date: 2024-07-26T18:05:52Z
• Authors: Zhiqiang Hu; Qi Jia; Shanglong Yao; Xiangdong Chen
• Keywords: H1-99; 0301 basic medicine; Science (General); TASK-3 channel; Lidocaine; Apoptosis; Social sciences (General); Sevoflurane; Q1-390; 03 medical and health sciences; Ovarian cancer; Propofol; Research Article

Different anesthetics exert different effects on the long-term outcomes of various cancers. The TWIK-related acid sensitive potassium 3 (TASK-3) channel is an important target and upregulated in However, role underlying mechanism TASK-3 ovarian cancer remain unknown. Here, we tested whether contributes to We found that was overexpressed human cell lines. Clinically relevant concentrations lidocaine, as a inhibitor, inhibitory tumor growth metastasis cells