Exploring Indonesian actinomycete extracts for anti-tubercular compounds: Integrating inhibition assessment, genomic analysis, and prediction of its target by molecular docking

• DOI: 10.1016/j.heliyon.2024.e35648
• Publication Date: 2024-08-04T14:14:10Z
• Authors: Arif Nurkanto; Masrukhin; Joseph Calvin Erd...; Muhammad Farrel E...; Ade Lia Putri; Shanti Ratnakomala; Ruby Setiawan; Ahmad Fathoni; Kartika Dyah Palupi; Yulia Rahmawati; Danang Waluyo; Erwahyuni Endang ...; Sri Pujiyanto; Yuji Sumii; Andria Agusta; Norio Shibata; Sohkichi Matsumoto; Tomoyoshi Nozaki
• Keywords: Docking (animal)

Tuberculosis (TB) is the foremost cause of infectious fatality globally. The primary global challenge in combatting TB lies addressing emergence drug-resistant variants disease. However, number newly approved agents for treating has remained remarkably low over recent decades. Hence, research endeavors discovering novel anti-TB are always needed. In present study, we screened 1,500 culture extracts from actinomycetes isolated Indonesia their inhibitory activity against