The risk of immune-mediated inflammatory diseases following exposure to childhood maltreatment: A retrospective cohort study using UK primary care data

• DOI: 10.1016/j.heliyon.2024.e40493
• Publication Date: 2024-11-16T02:23:19Z
• Authors: Liam Snook; Sonica Minhas; Vrinda Nadda; Ben Hammond; Krishna M. Gokhale; Julie Taylor; Caroline Bradbury...; Siddhartha Bandyo...; Krishnarajah Nira...; Nicola J. Adderley; Joht Singh Chandan
• Keywords: Retrospective cohort study; Social sciences (General); H1-99; Childhood maltreatment; Q1-390; Science (General); 0302 clinical medicine; Epidemiology; Autoimmune disease; Research Article

As a global public health issue, childhood maltreatment is associated with significant morbidity and mortality. We aimed to investigate the association between immune-mediated inflammatory disorders (IMIDs). conducted retrospective matched open cohort study using UK primary care database January 1, 1995 31, 2021. Clinical codes were used identify patients exposed who by general practice (GP), age, sex up four unexposed patients. Cox regression analysis was evaluate risk of developing IMIDs (inflammatory bowel disease, coeliac rheumatoid arthritis, psoriasis, multiple sclerosis, systemic lupus erythematosus) during follow-up in versus groups. 256,130 712,478 Those 1) at an increased Rheumatoid arthritis (aHR 1·39; 95 % CI 1·12-1·74) Psoriasis 1·16; 1·10-1·23), 2) not statistically significantly disease 0·87; 0·75-1·00), sclerosis 1·07; 0·77-1·49) erythematosus 1·28; 0·89-1·85) 3) reduced 0·74; 0·62-0·88) compared group. Childhood estimated affect one three children globally; therefore, psoriasis represents substantial contribution burden IMIDs. Implementation broad approaches prevent detect its negative downstream consequences, such as, IMID development, essential.