Effect of gender on the prognostic value of dobutamine stress myocardial contrast echocardiography

• DOI: 10.1016/j.hjc.2017.04.004
• Publication Date: 2017-04-22T06:46:03Z
• Authors: Constantina Aggeli; Kali Polytarchou; Ioannis Felekos; Kostas Zisimos; Erifili Venieri; Athanasios Verven...; Dimitrios Varvaro...; Kostantinos Touto...; Eleutherios Tsiamis; Dimitrios Tousoulis
• Keywords: Stress Echocardiography; Dobutamine

Dobutamine stress contrast echo (DSCE) has a well-established prognostic value in the context of coronary artery disease (CAD). However, data regarding its capability separately men and women are scarce. The aim current study was to assess gender-related differences performance DSCE.DSCE performed 2645 consecutive patients, who were classified into two groups depending on gender. Follow-up lasted 57.1±10.1 months. End points included all-cause mortality, cardiac death, late revascularization, hospitalizations. Survival analysis comparing women.Of patients (59.3±8.7 years), 69.1% men. DSCE positive 23.4% male while females, respective percentage 14.3%. There statistically significant difference between with regard end point occurrence (11.6% vs. 6.1%, p<0.05). Multivariate revealed that response strongest predictor adverse outcomes (Exp(B)=51.9, p<0.05) both groups. predictive model including results along clinical well without males females (C-index 0.93 0.87 respectively, p=NS).DSCE strong for known or suspected CAD, regardless patient This makes an attractive screening option whom CAD assessment can be challenging.