Is metabolic dysregulation associated with antidepressant response in depressed women in climacteric treated with individualized homeopathic medicines or fluoxetine? The HOMDEP-MENOP Study

• DOI: 10.1016/j.homp.2016.11.002
• Publication Date: 2017-01-10T15:46:43Z
• Authors: Emma del Carmen M...; Lidia Llanes-Gonz...; Leopoldo Aguilar-...; Juan Asbun-Bojalil
• Keywords: Depression; Dyslipidemia

Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that dysregulation may predict poor response to conventional antidepressants. Response treatment has not been studied in homeopathic medicine. The aim of this study was investigate the prevalence disorders depressed climacteric women treated medicines, fluoxetine or placebo, if these alterations have any association treatment. One hundred thirty-three Mexican (40–65 years) depression, enrolled HOMDEP-MENOP study, a randomized, placebo-controlled, double-blind, double-dummy, three-arm trial 6 week follow-up, underwent complete medical history clinical examination. Metabolic parameters were assessed at baseline. Association between baseline analyzed bivariate analysis three groups. Odds ratios (OR) their 95% confidence interval (95% CI) calculated. considered for inclusion logistic regression model they had statistically significant relationship rate on p < 0.05 clinically relevant. Overall combined (obesity overweight) 86.5%; 52.3% hypertriglyceridemia; 44.7% hypercholesterolemia; 46.7% insulin resistance; 16% subclinical hypothyroidism. There no dyslipidemia, overweight, resistance non-response homeopathy group [OR 1.57 (0.46–5.32), = 0.467; 0.37 (0.003–1.11), 0.059; 0.67 (0.16–2.7), 0.579, respectively]. significantly individualized (IHT), placebo. Due high its climacteric, further investigation should be focused whether prescriptions based classical an effect parameters, and/or treating same time could lead higher rates. ClinicalTrials.gov Identifier: NCT01635218 URL: http://clinicaltrials.gov/ct2/show/NCT01635218?term=depression+homeopathy&rank=1