Cancer risk and survival according to body mass index in hepatobiliary malignancies: a nationwide registry-based cohort study

• DOI: 10.1016/j.hpb.2023.07.882
• Publication Date: 2023-07-17T08:20:37Z
• Authors: Usman Saeed; Marie Nordsletten; Tor Å. Myklebust; Trude E. Robsahm; Bjørn Møller; Bjørn Steen Skålhegg; Tom Mala; Sheraz Yaqub
• Keywords: Gallbladder Cancer; Intrahepatic Cholangiocarcinoma; Liver Cancer

The aim of this study was to explore the associations between BMI and cancer liver, bile ducts, gallbladder.A registry-based cohort performed by linking data from several national registries in Norway.The comprised 1 723 692 individuals including 4768 hepatobiliary cases during 55 743 509 person-years follow-up. In men, we found increased risk per 5 kg/m2 increase for hepatocellular carcinoma extrahepatic cholangiocarcinoma. women there cholangiocarcinoma gallbladder cancer. Women with high early adulthood had intrahepatic Reduced cancer-specific survival all malignancies overweight obesity. reduced observed obesity cancers, except Increased cancer-death carcinoma, intra-, women. For positively associated cholangiocarcinoma.This supports notion an cancers increasing BMI, sex age variations. findings also suggest a higher BMI.