A prospective longitudinal study of health-related quality of life and psychological wellbeing after an implantable cardioverter-defibrillator in patients with genetic heart diseases

• DOI: 10.1016/j.hroo.2022.02.003
• Publication Date: 2022-02-08T22:47:51Z
• Authors: Lieke M. van den ...; Tanya Sarina; Joanna Sweeting; Laura Yeates; Kezia Bates; Catherine Spinks; Catherine O’Donnell; Samuel F. Sears; Kevin McGeechan; Christopher Semsa...; Jodie Ingles
• Keywords: Longitudinal Study

BackgroundGenetic heart diseases (GHDs) can be clinically heterogeneous and pose an increased risk of sudden cardiac death (SCD). The implantable cardioverter-defibrillator (ICD) is a lifesaving therapy. Impacts on prospective long-term psychological health-related quality life (HR-QoL) after ICD implant in patients with GHDs are unknown.ObjectivesInvestigate the functioning HR-QoL over time who receive ICD, identify factors for poor HR-QoL.MethodsA longitudinal, study design was used. Patients attending specialized clinic, diagnosed GHD which they received between May 2012 January 2015, were eligible. Baseline surveys completed prior to implantation 5-year follow-up implant. We measured (Hospital Anxiety Depression Scale, Florida Shock Scale), (Short-Form 36v2), device acceptance (Florida Patient Acceptance Scale).ResultsForty included (mean age 46.3 ± 14.2 years; 65.0% male). Mean measures within normative ranges during follow-up. After 12 months, 33.3% 19.4% participants showed elevated levels anxiety depression, respectively. Longitudinal mixed-effect analysis significant improvements from baseline first overall cohort, variability increasing 36 months. Nontertiary education female sex predicted worse mental time, while comorbidities depression physical HR-QoL.ConclusionWhile majority adjust well their implant, subset experience outcomes. Genetic unknown. Investigate HR-QoL. A Scale). Forty While