Metagenomics reveals structural and functional gut mycobiota dysbiosis in Tibetan subjects with coronary heart disease

• DOI: 10.1016/j.humgen.2023.201158
• Publication Date: 2023-02-25T07:48:18Z
• Authors: Qi Cheng; Liangzhi Zhang; Fengyun Liu; Chao Fan; Tianyi Wu; Yuan Li; Haiwen Hou; Yan Ma; Yueqing Tan; Yuxian Li; Yue Hai; Yanming Zhang
• Keywords: Mycobiota; Dysbiosis

Gut mycobiota play indispensable roles in human health. However, little is known about the alterations to gut and their correlations with coronary heart disease (CHD) Tibetan subjects. We conducted a study based on shotgun metagenomic sequencing of DNA extracted from faecal samples analyse taxonomic composition functional annotation 14 CHD patients, 13 patients non-stenosis (NCHD), 18 healthy controls (HT). The TMAO, creatinine, TG levels group were significantly higher than HT. alpha-diversity indices, including Richness, Shannon, Simpson, beta diversity different between relative abundances Anaeromyces robustus, Aspergillus taichungensis, Glomus cerebriforme, Monosporascus ibericus, Ophiocordyceps sinensis differed among three groups. There significant positive lipopolysaccharide (LPS) several metabolic pathways, thermogenesis, Alzheimer's disease, oxidative phosphorylation, Parkinson's cardiac muscle contraction. A redundancy analysis (RDA) revealed that LPS body mass index (BMI) strongly positively associated CHD. foregoing results demonstrated dysbiosis an important mechanism development