Ampicillin plus ceftriaxone therapy against Enterococcus faecalis endocarditis: A case report, guidelines considerations, and literature review

• DOI: 10.1016/j.idcr.2022.e01462
• Publication Date: 2022-03-02T17:24:08Z
• Authors: Andrea Marino; Antonio Munafò; Aldo Zagami; Manuela Ceccarelli; Edoardo Campanella; Federica Cosentino; Vittoria Moscatt; Giuseppina Cantar...; Rosaria Di Mauro; Renato Bernardini; Giuseppe Nunnari; Bruno Cacopardo
• Keywords: Enterococcus faecalis; Infective Endocarditis

Enterococcus faecalis infective endocarditis (EFIE) continues to be a very serious disease, showing considerable morbidity and mortality rates which are influenced by the spread of multi-drug resistant strains occurred in last decades. Although aminoglycosides were considered treatment choice EIFE, recent years several studies have investigated alternative therapeutic approaches, including combinations beta-lactams, mainly because aminoglycoside-renowned nephrotoxicity widespread development high-level resistance (HLAR). In this scenario, we reported case involving prosthetic valve caused an aminoglycoside-resistant E. strain was successfully treated with ampicillin plus ceftriaxone despite presence artificial heart patient's severe clinical conditions.