Hyaluronic acid coated spinel ferrite for combination of chemo and photodynamic therapy: Green synthesis, characterization, and in vitro and in vivo biocompatibility study

• DOI: 10.1016/j.ijbiomac.2022.08.036
• Publication Date: 2022-08-10T15:56:34Z
• Authors: Mostafa Zamani; Mozhgan Aghajanzadeh; Setare Jashnani; S. Shirin Shahangian; Farhad Shirini
• Keywords: 0301 basic medicine; Manganese; Curcumin; Photosensitizing Agents; Iron; Riboflavin; Ferric Compounds; 3. Good health; 03 medical and health sciences; Photochemotherapy; Doxorubicin; Nickel; Cell Line, Tumor; Neoplasms; Aluminum Oxide; Humans; Nanoparticles; Hyaluronic Acid; Magnesium Oxide

In this project, different photosensitizers were prepared using different ratios of nickel, manganese, and iron. Then, multiple analysis were performed to evaluate their efficiency, and the most suitable one was used to be coated by hyaluronic acid to improve the nano-platform's biocompatibility and target ability. Moreover, another chemical targeting agent (riboflavin) was used to further improve the target ability of the prepared nano-platform. Different spectroscopies and thermal analysis were used to determine the physical and chemical characteristics of the prepared nano-platform. Also, in order to determine the biocompatibility of the nano-platform, in vitro and in vivo tests such as blood hemolysis, blood aggregation and lethal dose were performed. Then, an anti-cancer agent (curcumin) was loaded on the selected nano-platform to makes us able utilizing the synergistic effect of chemotherapy and photodynamic therapy simultaneously. Finally, the cell cytotoxicity results showed that the prepared nano-platform had a great anti-cancer potential which can make it a great candidate as a dual photo and chemo therapy agent for treatment of breast cancers.