Artificial nonenzymatic antioxidant Prussian blue/KGM-BSA nanocomposite hydrogel dressing as ROS scavenging for diabetic wound healing

• DOI: 10.1016/j.ijbiomac.2024.131106
• Publication Date: 2024-03-27T16:39:01Z
• Authors: Dong-Xu Tang; Kun Liu; Jin-Yu Yang; Zhi-Jun Wang; Li-Li Fu; Xiao-Jie Yang; Yue-Sheng Li; Bin Huang; Yi Liu
• Keywords: Prussian blue; Bovine serum albumin

The process of diabetic wound healing was influenced by the excessive proliferation reactive oxygen species (ROS). Therefore, in wounds, it crucial to removing ROS. This study designed composited nanoparticles: KBP, consisted Konjac glucomannan, bovine serum albumin, and Prussian blue. Then they were embedded glucomannan hydroxypropyl trimethylammonium chloride chitosan composite hydrogel (KH), KBP@KH finally achieved excellent efficacy healing. vitro vivo experiments demonstrated that KPB nanoparticles exhibited favorable ROS scavenging capability biosafety. not only effectively eliminated from but also adaptability. facilitated angiogenesis suppressed production inflammatory factors. Overall, dressing characterized its user-friendly nature, safety, high efficiency.