In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19

• DOI: 10.1016/j.ijcard.2021.10.140
• Publication Date: 2021-10-25T12:57:47Z
• Authors: Hernan Mejia-Rent...; Alejandro Travieso; Adam Sagir; Eduardo Martínez-...; Angela Carrascosa...; Takumi Toya; Iván J. Núñez-Gil; Vicente Estrada; Amir Lerman; Javier Escaned
• Keywords: Reactive hyperemia; Endothelial Dysfunction

Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought investigate systemic endothelial function its temporal changes COVID-19 from a non-invasive approach reactive hyperemia peripheral arterial tonometry (PAT).This prospective, observational, case-control blinded study. The population was comprised by 3 groups: investigated during acute (group 1), past 2), controls 1:1 matched demographics cardiovascular risk factors 3). natural logarithmic scaled index (LnRHI), measure endothelium-mediated dilation arteries, obtained all participants compared between study groups.144 were enrolled (72 72 controls). Median time symptoms PAT assessment 9.5 101.5 days groups 1 2, respectively. LnRHI significantly lower group 2 both (0.53 ± 0.23 vs. 0.72 0.26 1, p = 0.0043; 0.79 3, < 0.0001). In addition, within it observed markedly decrease post infection stage (0.73 0.42 0.26, 0.0042).This suggests deleterious effect SARS-CoV-2 on function. These findings open new venues clinical implication prognostic role post-COVID syndrome using techniques.