N1‐(quinolin‐2‐ylmethyl)butane‐1,4‐diamine, a polyamine analogue, attenuated injury in in vitro and in vivo models of cerebral ischemia

• DOI: 10.1016/j.ijdevneu.2012.08.008
• Publication Date: 2012-09-11T20:06:12Z
• Authors: Juan Cen; Lu Liu; Ling He; Man Liu; Chao‐Jie Wang; Bian‐Sheng Ji
• Keywords: Polyamine; Ifenprodil

Abstract It has been widely recognized that glutamate (Glu)‐induced cytotoxicity, intracellular calcium overload and excessive free radical production are the key players in development progression of ischemic brain injury. Since MK‐801, an antagonist N‐methyl‐ d ‐aspartate (NMDA) receptor, showed many adverse reactions hampered its clinical applications, safe effective agent for treatment cerebral ischemia is eagerly required. This study was to investigate effects N 1 ‐(quinolin‐2‐ylmethyl)butane‐1,4‐diamine (QMA), a polyamine analogue, on vitro vivo models damage. The results revealed pretreatment with QMA could attenuate Glu, putrescine (Put) oxygen‐glucose deprivation (OGD)‐induced cell death, lipid peroxidation as well elevation reactive oxygen species (ROS) [Ca 2+ ] i pheochromocytoma (PC12) cells rat primary cortical neurons. also demonstrated inhibit NMDA‐mediated accumulation neurons reduce infarct volume middle artery occlusion (MCAO) rats. present report suggested polyamines played crucial role pathological processes damage or other novel analogues be promising therapeutic candidates stroke by virtue their anti‐hypoxia antioxidation property.