Effects of experimentally‐induced maternal hypothyroidism on crucial offspring rat brain enzyme activities

• DOI: 10.1016/j.ijdevneu.2014.03.002
• Publication Date: 2014-03-17T18:45:38Z
• Authors: Christos Koromilas; Charis Liapi; Apostolos Zarros; Vasileios Stolakis; Anastasia Tsagianni; Nikolina Skandali; Hussam Al‐Humadi; Stylianos Tsakiris
• Keywords: Neurochemical; Propylthiouracil

Abstract Hypothyroidism is known to exert significant structural and functional changes the developing central nervous system, can lead establishment of serious mental retardation neurological problems. The aim present study was shed more light on effects gestational and/or lactational maternal exposure propylthiouracil‐induced experimental hypothyroidism crucial brain enzyme activities Wistar rat offspring, at two time‐points their lives: birth (day‐1) 21 days age (end lactation). Under all studied conditions, offspring acetylcholinesterase (AChE) activity found be significantly decreased due hypothyroidism, in contrast adenosinetriphosphatase (Na + ,K ‐ATPase Mg 2+ ‐ATPase) that were only altered right after (increased decreased, respectively, following an hypothyroidism) restored control levels by end lactation. As our findings regarding pattern has above‐mentioned are compared those reported literature, several differences revealed could attributed both mode simulation approach followed as well time‐frames examined. These provide basis for a debate need consistent during neurodevelopment further evaluation herein presented discussed neurochemical (and, ultimately, neurodevelopmental) experimentally‐induced region‐specific manner.