Neonatal blockade of GABA‐A receptors alters behavioral and physiological phenotypes in adult mice

• DOI: 10.1016/j.ijdevneu.2017.01.007
• Publication Date: 2017-01-19T12:09:52Z
• Authors: Ali‐Akbar Salari; Mohammad Amani
• Keywords: Corticosterone; Elevated plus maze

Gamma-aminobutyric acid (GABA) plays an inhibitory role in the mature brain, and has a complex bidirectional effect different parts of immature brain which affects proliferation, migration differentiation neurons during development. There is also increasing evidence suggesting that activation or blockade GABA-A receptors early life can induce behavioral abnormalities adulthood. We investigated whether neonatal by bicuculline alter anxiety- depression-like behaviors, body weight, food intake, corticosterone testosterone levels adult mice (postnatal days 80-95). To this end, were treated with either DMSO (70, 150 300μg/kg) postnatal 7, 9 11. When grown to adulthood, exposed tests measure (elevated plus-maze light-dark box) behaviors (tail suspension test forced swim test). Stress-induced serum levels, weight intake evaluated. Neonatal exposure at dose 300μg/kg decreased anxiety-like behavior, stress-induced increased without significantly influencing behavior male mice. However, no significant changes these parameters observed females. These findings suggest physiological hormonal sex-dependent manner Taken together, data corroborate concept have important programming neurobehavioral phenotypes