Histoplasmosis and penicilliosis: Comparison of clinical features, laboratory findings and outcome

• DOI: 10.1016/j.ijid.2004.10.006
• Publication Date: 2005-10-20T10:20:38Z
• Authors: Piroon Mootsikapun; Sukanya Srikulbutr
• Keywords: Penicillium marneffei; Histoplasma; Dimorphic fungus

Histoplasmosis and penicilliosis are infections caused by the dimorphic fungi, Histoplasma capsulatum Penicillium marneffei, respectively. The aim of this study was to compare clinical presentation, laboratory radiologic findings outcome these at Srinagarind Hospital, Khon Kaen, Thailand.The medical records patients who had positive cultures for marneffei during 1996-2002 were reviewed. data compared analyzed Chi-square Fisher's exact tests.There 32 36 with H. P. infection, respectively, available review. most common underlying disease histoplasmosis acquired immunodeficiency syndrome (AIDS), which accounted 90.6% 91.7%, in both fever, weight loss, cough, anemia, lymphadenopathy, hepatomegaly splenomegaly. Frequencies skin lesions not statistically different between either group (P=0.20). Laboratory similar two infections, except hyperbilirubinemia, more (P=0.02). There abnormal X-ray groups interstitial infiltration abnormality.Histoplasmosis presentations, chest abnormalities. Itraconazole is recommended as secondary prophylaxis HIV-infected have or penicilliosis.