Changing trends in serotypes of S. pneumoniae isolates causing invasive and non-invasive diseases in unvaccinated population in Mexico (2000-2014)

• DOI: 10.1016/j.ijid.2017.02.005
• Publication Date: 2017-02-16T21:30:58Z
• Authors: María Noemí Carna...; Araceli Soto-Nogu...; Miguel Angel Sánc...; Fortino Solórzano...; María Elena Velaz...; Gabriela Echániz-...; Francisco Márquez...; Lucila Martínez-M...; María Elizabeth O...; Maria Guadalupe M...; Martha Camacho-Ve...; José Guillermo Vá...; Rosario Vázquez-L...; Eduardo Rivera-Ma...; Ana María Hernánd...; Briceida López-Ma...; Sarbelio Moreno-E...; Ernesto Calderón-...; Yolanda Jiménez-T...; José Luís Arredon...; Mercedes Macías-P...; Patricia Arzate-B...; Napoleón González...; José Sifuentes-Os...; Alfredo Ponce de ...; Ana Lilia Rolón-M...; Rosa Areli Martín...; Patricia Volkow-F...; Patricia Cornejo-...; José Manuel Felic...; Ismelda López-Ovilla; Juan Manuel Baraj...; Jorge Alejandro V...; Alejandra Cendeja...; María del Rosario...; Andrés Flores Santos; Martín Magaña-Aquino; Antonio Luévanos-...; Rayo Morfín-Otero; Eduardo Rodríguez...; Sergio Esparza-Ah...; Guadalupe Atilano...; Norma de la Re-Mo...; Martha Anchondo-M...; Jesús Contreras-Soto; Ana Dolores Quint...; Jacobo Ayala-Aguilar; Claudia E. Guajar...; Elvira Garza-Gonz...; oaquín Rincón-Zuno; Domingo Sánchez-F...; Verónica Andrade-...; Reyna Edith Corte...; María del Socorro...; Socorro Azarell A...; Juan Luis Mosqued...; Mariana Gil-Veloz; Javier Castellano...; Juan Carlos Tinoc...; Lorena Salcido-Gu...; Rosalía Jarillo-M...; Jessica Paola-Pur...; Dinora Aguilar-Es...; Ana Rosa Méndez-Cruz; Leova Pacheco-Gil; Edgardo S. Aceved...; Alma Rosa Gonzále...; María del Carmen ...; Manuel Ibarra-Muñiz; Paul Mora-Dominguez
• Keywords: Pneumococcal Conjugate Vaccine; Herd Immunity; Pneumococcal infections

Introduction of pneumococcal conjugate vaccines (PCV) targeted against a limited number serotypes substantially decreased invasive (IPD) and non-invasive diseases (NIPD) but it was accompanied by non-vaccine type replacement disease. After 9 years introduction PCV in Mexico, we analyze the evidence indirect effects on IPD NIPD serotype distribution among groups not to receive vaccine.From January 2000 December 2014, strains isolated from cases patients ≥5 age participant hospitals SIREVA II (Sistema Regional de Vacunas) network were serotyped. A regression analysis performed considering year proportion included different vaccine formulations (PCV7, PCV10 PCV13). The slope obtained for each line their correspondent p-value. pre-PCV7 post-PCV7 periods evaluated χ2 test.From total 1147 recovered, 570 corresponded 577 periods. three 2.4, 2.6 1.3%, respectively per during study period. significant increase 19A observed post-vaccine period all groups.A percentage annual decline causing detected vaccine, probably due herd effect. Considering is dynamic process, highlight importance surveillance programs.