Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia
Adult
Male
Reticulocytes
Infectious and parasitic diseases
RC109-216
Anemia, Sickle Cell
Comorbidity
Article
Cohort Studies
Leukocyte Count
03 medical and health sciences
0302 clinical medicine
Acute Chest Syndrome
Humans
Lymphocyte Count
Prospective Studies
L-Lactate Dehydrogenase
Platelet Count
SARS-CoV-2
Sickle cell anaemia
Vasooclusive crises
COVID-19
SCA
3. Good health
Coronavirus
Hospitalization
Ferritins
Female
DOI:
10.1016/j.ijid.2021.03.044
Publication Date:
2021-03-18T17:20:08Z
AUTHORS (13)
ABSTRACT
The study aimed to assess COVID-19 impact on the morbidity and mortality of vasooclusive crisis (VOC) in sickle cell anaemia (SCA) patients.A prospective cohort study of 100 SCA patients; 50 with COVID-19 (COVID group) and 50 without (non-COVID group). All patients signed written informed consent.The COVID group had a significantly higher VOC episode median per year; 3 (IQR,1-6) vs 2 (IQR,2-12) (P < 0.05). The need for hospitalisation was similar in both groups. The non-COVID group had more history of culture-proven infection (P = 0.05). The COVID-group had more osteonecrosis (P < 0.05), splenic sequestration, splenomegaly and hepatic crisis (P = 0.05, 0.006, 0.02; respectively) and significantly higher (P < 0.05) symptoms of fever, cough, fatigue, abdominal pain and anosmia. Mean haemoglobin, lymphocyte subset, platelets, and reticulocytes were reduced in both groups, while lactate dehydrogenase and ferritin levels were significantly elevated. In the COVID group, the rise in white blood cell count, reticulocyte percentage, platelets and ferritin was subdued (P < 0.05). Two patients in the COVID group and 3 in the non-COVID group died; there was no statistically significant difference in mortality.Although COVID-19 may have triggered the onset of VOC, it did not significantly influence VOC-related morbidity or mortality in this SCA cohort.
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