SARS-CoV-2 reinfection with a virus harboring mutation in the Spike and the Nucleocapsid proteins in Panama

• DOI: 10.1016/j.ijid.2021.06.004
• Publication Date: 2021-06-06T15:06:33Z
• Authors: Yamilka Díaz; Anyuri Ortiz; Adriana Weeden; Daniel Castillo; Claudia González; Brechla Moreno; Mabel Martínez-Mo...; Marlene Castillo; Grettel Vasquez; Lisseth Sáenz; Danilo Franco; Yaneth Pitti; Oris Chavarria; Jessica Gondola; Ambar M. Moreno; Leyda Ábrego; Davis Beltrán; Ilka Guerra; Jim Chang; Zumara Chaverra; Isela Guerrero; Alejandra Valoy; Melissa Gaitán; Dimelza Araúz; Ernesto Morán; Maria Chen-Germán; Elimelec Valdespino; Rita Rodríguez; Rita Corrales; Roderick Chen-Camaño; Juan Miguel Pascale; Alexander A. Mart...; Sandra López-Vergès
• Keywords: 0301 basic medicine; 03 medical and health sciences; SARS-CoV-2; Panama; Reinfection; Mutation; COVID-19; Case Report; Infectious and parasitic diseases; RC109-216; 3. Good health

We report a case of reinfection by SARS-CoV-2 with the second virus harboring amino acid changes in the Spike protein (141-143del, D215A, ins215AGY, L452R, D614G), orf1a, helicase, orf3a, and Nucleocapside. The virus associated with the reinfection, from an endemic lineage containing the S:L452R immune escape mutation, was circulating in Panama at the time.