Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso

• DOI: 10.1016/j.ijid.2022.02.034
• Publication Date: 2022-02-26T06:57:27Z
• Authors: Toussaint Rouamba; Esperance Ouédraogo; Houreratou Barry; Nobila Valentin Y...; Apoline Sondo; Rainatou Boly; Jacques Zoungrana; Abdoul Risgou Oué...; Marc Christian Ta...; Armel Poda; Arnaud Eric Diendéré; Abdoul-Salam Oued...; Innocent Valea; Isidore Traoré; Zekiba Tarnagda; Maxime K Drabo; Halidou Tinto
• Keywords: Hydroxychloroquine; 2019-20 coronavirus outbreak

ObjectivesOur study aimed to assess the statistical relationship between use of chloroquine phosphate or hydroxychloroquine plus azithromycin (CQ/HCQ + AZ) and virological recovery, disease worsening, death among out- inpatients with COVID-19 in Burkina Faso.Methods DesignsThis was a retrospective observational that compared outcomes terms time patients who received CQ/HCQ AZ those did not using multivariable Cox Poisson model before after propensity matching.ResultsOf 863 included study, about 50% (432/863) were home-based follow-up inpatients. Of these, 83.3% (746/863) at least 1 dose 13.7% (118/863) not. There no significant differences associated recovery for receiving any (adjusted HR 1.44; 95% CI 0.76–2.71). Similarly, there association worsening IRR 0.80; 0.50–1.50). However, untreated group, treated group had lower risk 0.20; 0.10–0.44).ConclusionsThe provided valuable additional information on show harmful treatment.