Disseminated mycobacterial infections after tumor necrosis factor inhibitor use, revealing inborn errors of immunity

• DOI: 10.1016/j.ijid.2023.04.007
• Publication Date: 2023-04-08T14:53:47Z
• Authors: Jacqueline D. Squire; Claudia R. Libertin; Harry Powers; Jared Nelson; Lisa Brumble; Federico R. Laham; Anahita Agharahimi; Alexandra F. Freeman; Jennifer W. Leiding
• Keywords: Nontuberculous Mycobacteria

Tumor necrosis factor-a inhibitors can be associated with increased risk of infections, particularly reactivation latent tuberculosis or nontuberculous mycobacterium (NTM). However, because disseminated NTM is rare, inborn errors immunity should considered. We present three patients after tumor inhibitor use who were found to have immunity.