Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings
Hematologic malignancy
Pandemic
Hematological Malignancy
DOI:
10.1016/j.ijid.2023.10.013
Publication Date:
2023-10-18T16:12:56Z
AUTHORS (187)
ABSTRACT
Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.We analyzed elderly (age groups: 65-70, 71-75, 76-80, and >80 years old) included EPICOVIDEHA registry between January 2020 July 2022. Univariable multivariable Cox regression models were conducted to identify factors influencing death hematological malignancy.The study data from 3,603 (aged 65 or older) malignancy, a majority being male (58.1%) significant proportion having comorbidities. divided into four groups, analysis assessed outcomes, vaccination status, other variables relation pandemic waves. 90-day survival rate for was 71.2%, differences groups. waves had varying impacts, first wave affecting over 80 old, second more third least all Factors contributing mortality age, comorbidities, lymphopenia, active acute leukemia, less than three vaccine doses, COVID-19, using only corticosteroids as treatment.These underscore heterogeneity patients, highlight impacts pivotal importance vaccination, may help planning future healthcare efforts.
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