Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model

• DOI: 10.1016/j.ijpharm.2019.02.038
• Publication Date: 2019-02-27T21:31:19Z
• Authors: Jonas Rudén; Göran Frenning; Tobias Bramer; Kyrre Thalberg; Junxue An; Göran Alderborn
• Keywords: Morphology

The aim of this study was to investigate how the carrier morphology affects expression blend states in adhesive mixtures as a function surface coverage ratio (SCR) and identify where transitions between different occur. Adhesive five lactose carriers with varying contents fines, corresponding blends SCR ranging from 0 6, were produced by low-shear mixing. powder mechanics characterized bulk density, compressibility permeability. appearance studied scanning electron microscopy, light microscopy atomic force microscopy. size had crucial impact on evolution state, affected mechanical properties mixtures. It found that smaller little or no irregularities more sensitive additions fines resulting self-agglomeration at relatively low values. On contrary, irregular structures larger sizes able reach higher values before occurred. This could be attributed an increased deagglomeration efficiency predominantly adhering open pores.