Coumarin-poly(2-oxazoline)s as synergetic and protein-undetected nanovectors for photodynamic therapy

• DOI: 10.1016/j.ijpharm.2024.124186
• Publication Date: 2024-05-01T12:39:11Z
• Authors: Diana Heaugwane; Orélia Cerlati; Kedafi Belkhir; Belkacem Tarek Be...; Sylvain Catrouillet; Isabelle Fabing; Catherine Claparols; Marc Vedrenne; Dominique Goudoun...; Bruno Payré; Beatrice Lucia Bona; Alice Tosi; Francesca Baldell...; Patricia Vicendo; Vincent Lapinte; Barbara Lonetti; Anne-Françoise Mi...; Laure Gibot
• Keywords: Oxazoline

Because of the difficult challenges nanopharmaceutics, development a variety nanovectors is still highly desired. Photodynamic therapy, which uses photosensitizer to locally produce reactive oxygen species kill undesired cells, typical example for encapsulation has been shown be beneficial. The present work describes use coumarin-functionalized polymeric based on self-assembly amphiphilic poly(2-oxazoline)s. Encapsulation pheophorbide a, known PDT photosensitizer, lead an increased efficiency compared un-encapsulated version. Interestingly, presence coumarin both enhances desired photocytotoxicity and enables crosslinking vectors. Various are examined, differing by their size, shape hydrophilicity. Their behaviour in protocols HCT116 cells monolayers described, influence commented. Furthermore, formation protein corona assessed.