X-ray volumetric imaging in image-guided radiotherapy: The new standard in on-treatment imaging

• DOI: 10.1016/j.ijrobp.2005.09.018
• Publication Date: 2005-12-16T12:13:23Z
• Authors: Catherine A. McBain; Ann M. Henry; Jonathan Sykes; Ali Amer; Tom Marchant; Christopher M. Moore; Julie Davies; Julia Stratford; Claire McCarthy; Bridget Porritt; Peter Williams; Vincent S. Khoo; Pat Price
• Keywords: Male; Radiotherapy Planning, Computer-Assisted; Radiotherapy Dosage; Thoracic Neoplasms; 3. Good health; Central Nervous System Neoplasms; 03 medical and health sciences; 0302 clinical medicine; Head and Neck Neoplasms; Abdominal Neoplasms; Neoplasms; Humans; Radiographic Image Interpretation, Computer-Assisted; Female; Prospective Studies; Radiotherapy, Intensity-Modulated; Tomography, X-Ray Computed; Pelvic Neoplasms

X-ray volumetric imaging (XVI) for the first time allows for the on-treatment acquisition of three-dimensional (3D) kV cone beam computed tomography (CT) images. Clinical imaging using the Synergy System (Elekta, Crawley, UK) commenced in July 2003. This study evaluated image quality and dose delivered and assessed clinical utility for treatment verification at a range of anatomic sites.Single XVIs were acquired from 30 patients undergoing radiotherapy for tumors at 10 different anatomic sites. Patients were imaged in their setup position. Radiation doses received were measured using TLDs on the skin surface. The utility of XVI in verifying target volume coverage was qualitatively assessed by experienced clinicians.X-ray volumetric imaging acquisition was completed in the treatment position at all anatomic sites. At sites where a full gantry rotation was not possible, XVIs were reconstructed from projection images acquired from partial rotations. Soft-tissue definition of organ boundaries allowed direct assessment of 3D target volume coverage at all sites. Individual image quality depended on both imaging parameters and patient characteristics. Radiation dose ranged from 0.003 Gy in the head to 0.03 Gy in the pelvis.On-treatment XVI provided 3D verification images with soft-tissue definition at all anatomic sites at acceptably low radiation doses. This technology sets a new standard in treatment verification and will facilitate novel adaptive radiotherapy techniques.