Pulsed Reduced Dose Rate Reirradiation for Recurrent Primary Central Nervous System Tumors

• DOI: 10.1016/j.ijrobp.2015.07.834
• Publication Date: 2015-10-17T05:38:34Z
• Authors: E.S. Murphy; K. Rogacki; J.H. Suh; M. Ahluwalia; C.A. Reddy; J.S. Yu; P. Qi; G.H.J. Stevens; D. Peereboom; S.T. Chao
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Pulsed reduced dose rate (PRDR) is a re-irradiation technique that can be used in patients with recurrent gliomas and other central nervous system tumors who have previously received conventional radiation therapy. PRDR thought to target dividing neoplastic cells while permitting intratherapy sublethal damage repair irradiated normal tissue. Progression survival data not well known using this technique. This study evaluates the outcomes of primary brain re-irradiation. A retrospective review was performed included total 24 treated Data collected number prior interventions, diagnosis, tumor grade, therapy fractionation, time progression, survival. The 25 MU/minute pause between beams simulate 6.67 MU/minute. Cox proportional hazards regression evaluate prognostic factors. Survival times were calculated Kaplan-Meier method. (7 grade II, 7 III, 8 IV glioma 1 malignant peripheral nerve sheath craniopharyngioma) underwent August 2012 December 2014. median age KPS at 53 80, respectively. Median from initial treatment 48.3 months (R: 16.5 387.7 mos). 54 Gy 38-60 Gy) 30 fractions 15-33). 16.2 mos progression free 3.0 2.0 17+ Time therapy, age, KPS, concurrent chemotherapy for or on univariate analysis. Recurrent continue progress quickly despite without chemotherapy. More experience needed utility these patients. Moving forward, areas focus will include characterizing adverse events associated as role antiangiogenic tumors.