Renal cell carcinoma with early skin metastasis and partial response on tyrosine kinase inhibitor: A case report

• DOI: 10.1016/j.ijscr.2022.107020
• Publication Date: 2022-04-05T06:14:56Z
• Authors: Agus Rizal Ardy H...; Reginald Rustandi; Sahat Matondang; Meilania Saraswati; Lenny Sari; Sonar Soni Panigoro
• Keywords: 0303 health sciences; 03 medical and health sciences; Case Report; 3. Good health

Renal cell carcinoma (RCC) skin metastasis is a rare disease. However, there are no data on the effect of a Tyrosine Kinase Inhibitor (TKI) on its treatment.A 54-year-old male patient with renal cell carcinoma developed subcutaneous metastasis three months after radical nephrectomy and there was no discoloration or pain. Furthermore, an excision biopsy confirmed the metastatic lesion, and pazopanib was initiated as a treatment method. After 1-month of treatment, the patient developed ulceration and subsided after treatment was stopped. Similarly, a follow-up PET scan was performed almost a year after stopping the treatment, which showed improvement over metastatic pulmonary lesions.Renal cell carcinoma (RCC) major metastases were observed in pulmonary, costal, and skin. Tumor burden and location of metastasis influences progression free-survival of RCC patients treated with TKI.In this case, TKI treatment showed a long-term partial response, despite its lack of continuous therapy.