Selenium nanoparticles enhance the anti-tumor immune responses of anti-4-1BB antibody and alleviate the adverse effects on mice

• DOI: 10.1016/j.imbio.2024.152839
• Publication Date: 2024-07-31T01:58:34Z
• Authors: Lei zhang; Houru Liu; Jie Shen; Wenting Liu; Dahai Liu; Liansheng Cheng; Bei Huang
• Keywords: Lewis lung carcinoma; Cancer Immunotherapy

4-1BB agonists for cancer immunotherapy have shown good preliminary efficacy in clinical trials, but several of the first-generation agonistic antibodies entering clinic failed due to safety issues. Selenium nanoparticles (SeNPs) exhibit anti-inflammatory, anti-tumor, antioxidant, and immune-modulating properties. In addition, they been detoxifying effects prevent oxidative liver damage. this study, we used an anti-4-1BB antibody combination with SeNPs evaluate anti-lung vitro vivo experiments explore underlying mechanisms by pathological analyses, quantitative PCR, enzyme-linked immunoassay. We found that 5 μmol·L