CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness

• DOI: 10.1016/j.immuni.2023.03.010
• Publication Date: 2023-04-07T14:32:47Z
• Authors: Simona Mutascio; Talia Mota; Lavinia Franchitti; Ashish A. Sharma; Abigail Willemse; Sydney N. Bergstr...; Hong Wang; Maura Statzu; Gregory K. Tharp; Jared Weiler; Rafick-Pierre Sékaly; Steven E. Bosinger; Mirko Paiardini; Guido Silvestri; R. Brad Jones; Deanna A. Kulpa
• Keywords: Virus latency; Ex vivo

HIV infection persists during antiretroviral therapy (ART) due to a reservoir of latently infected cells that harbor replication-competent virus and evade immunity. Previous ex vivo studies suggested CD8