Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection

• DOI: 10.1016/j.immuni.2023.11.018
• Publication Date: 2023-12-28T15:31:45Z
• Authors: Tommaso Torcellan; Christin Friedrich; Rémi Doucet-Ladevèze; Thomas Ossner; Virgínia Visaconi...; Sofie Riedmann; Milas Ugur; Fabian Imdahl; Stephan P. Rosshart; Sebastian J. Arnold; Mercedes Gomez de...; Nicola Gagliani; Richard A. Flavell; Simone Backes; Wolfgang Kastenmü...; Georg Gasteiger
• Keywords: 0303 health sciences; 03 medical and health sciences; 610; Article

Natural killer (NK) cells are present in the circulation and can also be found residing tissues, these populations exhibit distinct developmental requirements thought to differ terms of ontogeny. Here, we investigate whether circulating conventional NK (cNK) develop into long-lived tissue-resident (trNK) following acute infections. We that viral bacterial infections skin triggered recruitment cNK their differentiation Tcf1