Anti-inflammatory properties of rose oxide

• DOI: 10.1016/j.intimp.2012.10.015
• Publication Date: 2012-11-01T13:31:50Z
• Authors: Fabiana Regina No...; Danielle Gomes Sa...; Flavielle Martins...; Gisele Graça Leit...; Danielle Brustolim; Enilton A. Camargo; Damião P. de Sousa; Milena Botelho Pe...; Cristiane Flora V...
• Keywords: Carrageenan; Intraperitoneal injection; Anti-inflammatory

Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties investigate possible mechanisms involved with its effects. RO first suggested by formalin test mice, an inflammatory pain model, because intraperitoneal (i.p.) administration (50 100mg/kg) inhibited only late phase test. To further RO, complete Freund's adjuvant (CFA)- carrageenan-induced paw inflammation models were used. Pre-treatment significantly reduced edema at 4, 6 24h after CFA injection. In addition, (100mg/kg) IL-1β, but not TNF-α, local production induced CFA. Administration (25-100mg/kg) decreased carrageenan rats, which more evident 3 4h induction. neutrophil migration hind measured MPO assay 25-100mg/kg, stimulus. another experimental set, leukocyte peritonitis model mice. results described here report strongly suggest that possesses related ability inhibit IL-1β migration.