α1-Antitrypsin-primed tolerogenic dendritic cells prolong allograft kidney transplants survival in rats

• DOI: 10.1016/j.intimp.2015.12.038
• Publication Date: 2016-01-04T22:45:22Z
• Authors: Guodong Chen; Jun Li; Lizhong Chen; Xingqiang Lai; Jiang Qiu
• Keywords: Graft Rejection; Male; Graft Survival; Cell Differentiation; Forkhead Transcription Factors; Dendritic Cells; Allografts; Kidney Transplantation; T-Lymphocytes, Regulatory; Rats; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Rats, Inbred Lew; alpha 1-Antitrypsin; Immune Tolerance; Animals; Cytokines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Cells, Cultured

• α1-Antitrypsin (AAT) induces tolerogenic dendritic cells (DC) which highly express indoleamine 2,3-dioxygenase (IDO).