Daucosterol suppresses dextran sulfate sodium (DSS)-induced colitis in mice
0301 basic medicine
0303 health sciences
Colon
Dextran Sulfate
Anti-Inflammatory Agents
Colitis
Sitosterols
T-Lymphocytes, Regulatory
3. Good health
Killer Cells, Natural
Mice, Inbred C57BL
03 medical and health sciences
Animals
Cytokines
Female
Lymph Nodes
Spleen
DOI:
10.1016/j.intimp.2019.03.062
Publication Date:
2019-04-09T06:57:32Z
AUTHORS (12)
ABSTRACT
The effects of daucosterol have been identified in cancer therapy and neuronal diseases. However, the regulatory function of daucosterol in DSS-induced colitis has not yet been investigated. In this study, we evaluated the immunological and therapeutic effects of daucosterol in a mouse model of dextran sulfate sodium (DSS)-induced colitis. Unlike vehicle mice, mice pre- or post-treated with daucosterol showed inhibition of body weight loss and the decrease in the disease activity index (DAI). In addition, daucosterol treatment rescued the DSS-induced decrease in colon length and disruption of the epithelial lining. Furthermore, it reduced DSS-induced production of reactive oxygen species (ROS), infiltration of macrophages, and expression of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β. Mice with colitis showed a decreased population of Foxp3+ cells, which was upregulated by daucosterol treatment. Furthermore, daucosterol increased natural killer (NK) cell activity and inhibited excessive IgA levels in mice with DSS-induced colitis. Collectively, our findings demonstrated that daucosterol significantly alleviated DSS-induced colitis, indicating the possibility of daucosterol as a therapeutic option for colitis.
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