MRG15 aggravates sepsis-related liver injury by promoting PCSK9 synthesis and secretion

• DOI: 10.1016/j.intimp.2024.112898
• Publication Date: 2024-08-10T06:38:32Z
• Authors: Boyuan Gu; Yu Jiang; Zhiwei Huang; Han Li; Wenhao Yu; Tongxi Li; Chen Liu; Pengru Wang; Jiatong Chen; Lei Sun; Peng Tan; Wenguang Fu; Jian Wen
• Keywords: PCSK9; Organ dysfunction

Disorders of lipid oxidation play an important role in organ damage, and metabolites are associated with inflammation coagulation dysfunction sepsis. However, the specific molecular mechanism by which metabolism-related proteins regulate sepsis is still unclear. The aim this study to investigate mortality factor 4-like protein 1 (MORF4L1, also called MRG15), a hepatic metabolism related gene, sepsis-induced liver injury.