Flexible Multiplexed In2O3 Nanoribbon Aptamer-Field-Effect Transistors for Biosensing
0301 basic medicine
Bioelectronics
Data Management and Data Science
Science
Q
Neurosciences
540
Nanotechnology Fabrication
Article
3. Good health
Nanoscience
03 medical and health sciences
Engineering
Information and Computing Sciences
Biomedical Imaging
Biotechnology
DOI:
10.1016/j.isci.2020.101469
Publication Date:
2020-08-18T02:38:11Z
AUTHORS (10)
ABSTRACT
Flexible sensors are essential for advancing implantable and wearable bioelectronics toward monitoring chemical signals within and on the body. Developing biosensors for monitoring multiple neurotransmitters in real time represents a key in vivo application that will increase understanding of information encoded in brain neurochemical fluxes. Here, arrays of devices having multiple In2O3 nanoribbon field-effect transistors (FETs) were fabricated on 1.4-μm-thick polyethylene terephthalate (PET) substrates using shadow mask patterning techniques. Thin PET-FET devices withstood crumpling and bending such that stable transistor performance with high mobility was maintained over >100 bending cycles. Real-time detection of the small-molecule neurotransmitters serotonin and dopamine was achieved by immobilizing recently identified high-affinity nucleic-acid aptamers on individual In2O3 nanoribbon devices. Limits of detection were 10 fM for serotonin and dopamine with detection ranges spanning eight orders of magnitude. Simultaneous sensing of temperature, pH, serotonin, and dopamine enabled integration of physiological and neurochemical data from individual bioelectronic devices.
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