Flexible Multiplexed In2O3 Nanoribbon Aptamer-Field-Effect Transistors for Biosensing

• DOI: 10.1016/j.isci.2020.101469
• Publication Date: 2020-08-18T02:38:11Z
• Authors: Qingzhou Liu; Chuanzhen Zhao; Mingrui Chen; Yihang Liu; Zhiyuan Zhao; Fanqi Wu; Zhen Li; Paul S. Weiss; Anne M. Andrews; Chongwu Zhou
• Keywords: Bioelectronics; Aptamer; Neurochemical

Flexible sensors are essential for advancing implantable and wearable bioelectronics toward monitoring chemical signals within on the body. Developing biosensors multiple neurotransmitters in real time represents a key vivo application that will increase understanding of information encoded brain neurochemical fluxes. Here, arrays devices having In2O3 nanoribbon field-effect transistors (FETs) were fabricated 1.4-μm-thick polyethylene terephthalate (PET) substrates using shadow mask patterning techniques. Thin PET-FET withstood crumpling bending such stable transistor performance with high mobility was maintained over >100 cycles. Real-time detection small-molecule serotonin dopamine achieved by immobilizing recently identified high-affinity nucleic-acid aptamers individual devices. Limits 10 fM ranges spanning eight orders magnitude. Simultaneous sensing temperature, pH, serotonin, enabled integration physiological data from bioelectronic