Real-time monitoring of deformed wing virus-infected bee foraging behavior following histone deacetylase inhibitor treatment
0301 basic medicine
570
0303 health sciences
03 medical and health sciences
Molecular biology
Science
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Ethology
Omics
Entomology
Article
3. Good health
DOI:
10.1016/j.isci.2021.103056
Publication Date:
2021-09-28T16:00:42Z
AUTHORS (9)
ABSTRACT
Impairment in the learning/memory behavior of bees is responsible for the massive disappearance of bee populations and its consequent agricultural economic losses. Such impairment might be because of o both pesticide exposure and pathogen infection, with a key contributor deformed wing virus (DWV). The present study found that sodium butyrate (NaB) significantly increased survival and reversed the learning/memory impairment of DWV-infected bees. A next-generation sequencing analysis showed that NaB affected the expression of genes involved in glycolytic processes and memory formation, which were suppressed by DWV infection. In addition, we performed a large-scale movement tracking experiment by using a wireless sensor network-based automatic real-time monitoring system and confirmed that NaB could improve the homing ability of DWV-infected bees. In short, we demonstrated the mechanism of how epigenetic regulation can resume the memory function of honeybees and suggest strategies for applying NaB to reduce the incidence of colony losses.
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