Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure

• DOI: 10.1016/j.isci.2022.104764
• Publication Date: 2022-07-16T10:12:47Z
• Authors: Nicole Marzan-Rivera; Crisanta Serrano-...; Lorna Cruz; Petraleigh Pantoja; Alexandra Ortiz-Rosa; Teresa Arana; Melween I. Martinez; Armando G. Burgos; Chiara Roman; Loyda B. Mendez; Elizabeth Geerling; Amelia K. Pinto; James D. Brien; Carlos A. Sariol
• Keywords: Flavivirus; Heterologous

The link between CD4+ T and B cells during immune responses to DENV ZIKV their roles in cross-protection heterologous infection is an active area of research. Here we used lymphocyte depletions dissect the impact cellular immunity on humoral a tertiary flavivirus macaques. We show that depletion DENV/ZIKV-primed animals followed by resulted dysregulated adaptive responses. delay DENV-specific IgM/IgG antibody titers binding neutralization CD4-depleted but not ZIKV/DENV-primed animals. This study confirms critical role priming early effective response sequential infections. Our work here suggests order exposure affects outcome infection. findings have implications for understanding complex development vaccines.