Yin and yang of cannabinoid CB1 receptor: CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity

• DOI: 10.1016/j.isci.2022.104994
• Publication Date: 2022-08-24T03:51:58Z
• Authors: Kathryn Miranda; William Becker; Philip B. Busbee; Nicholas Dopkins; Osama A. Abdulla; Yin Zhong; Jiajia Zhang; Mitzi Nagarkatti; Prakash S. Nagark...
• Keywords: Immune receptor

While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types not tested. The current study investigated the CB1 immune vs non-immune cells during DIO by generating radiation-induced bone marrow chimeric mice that expressed functional all except or only cells. CB1-/- recipient hosts were resistant DIO, indicating is necessary for induction DIO. Interestingly, chimeras with showed exacerbation combined infiltration bone-marrow-derived macrophages brain and visceral adipose tissue, elevated food intake, increased glucose intolerance. These results demonstrate opposing hematopoietic versus non-hematopoietic suggests targeting receptors provides a new pathway ameliorate related metabolic disorders.