The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

• DOI: 10.1016/j.isci.2023.105991
• Publication Date: 2023-01-18T17:01:56Z
• Authors: Naomi G. Wilson; Ariel Hernandez-L...; Anne L. Rosen; Natalia Jaeger; Ryan T. McDonough; Jesus Santiago-Bo...; Michael A. Lint; Thomas R. Rosen; Christopher P. To...; Leonard B. Bacharier; S. Joshua Swamidass; Andrew L. Kau
• Keywords: 0301 basic medicine; 03 medical and health sciences; Science; Q; ICTS (Institute of Clinical and Translational Sciences); Medicine and Health Sciences; Immunity; Medical microbiology; Article; 3. Good health

The gut microbiota in early childhood is linked to asthma risk, but may continue affect older patients with asthma. Here, we profile the of 38 children (19 asthma, median age 8) and 57 adults (17 28) by 16S rRNA sequencing find individuals harbored compositional differences from healthy controls both children. We develop a model aid design mechanistic experiments gnotobiotic mice show enterotoxigenic Bacteroides fragilis (ETBF) more prevalent compared controls. In mice, ETBF, modulated community context, can increase oxidative stress lungs during allergic airway inflammation (AAI). Our results provide evidence that ETBF affects phenotype subset which suggests therapies targeting be helpful tools for control.