An epigenetic signature of advanced colorectal cancer metastasis

• DOI: 10.1016/j.isci.2023.106986
• Publication Date: 2023-05-28T13:34:53Z
• Authors: Euan J. Rodger; Gregory Gimenez; Priyadarshana Aji...; Peter A. Stockwell; Suzan Almomani; Sarah A. Bowden; Anna L. Leichter; Antonio Ahn; Sharon Pattison; John L. McCall; Sebastian Schmeier; Frank A. Frizelle; Michael R. Eccles; Rachel V. Purcell; Aniruddha Chatterjee
• Keywords: Epigenomics

Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority CRC deaths are caused by tumor metastasis, even following treatment. There strong evidence for epigenetic changes, such as DNA methylation, accompanying metastasis poorer patient survival. Earlier detection better understanding molecular drivers critical clinical importance. Here, we identify signature advanced performing whole genome-scale methylation full transcriptome analyses paired primary cancers liver metastases from patients. We observed striking differences between metastatic pairs. A subset loci showed coordinated methylation-expression suggesting these potentially that control the expression genes in cascade. identification epigenomic markers has potential to enable outcome prediction lead discovery new therapeutic targets.