CSL362 potently and specifically depletes pDCs in vitro and ablates SLE-immune complex-induced IFN responses

• DOI: 10.1016/j.isci.2023.107173
• Publication Date: 2023-06-20T01:25:33Z
• Authors: Katherine A. Mona...; Alberta Hoi; Cristina Gamell; Tsin Yee Tai; Bryan Linggi; Jarrat Jordan; Matteo Cesaroni; Takahiro Sato; Milica Ng; Shereen Oon; Jacqueline Benson; Ian Wicks; Eric Morand; Nicholas Wilson
• Keywords: Interferon type I

Systemic lupus erythematosus (SLE) is an autoimmune disease with significant morbidity and mortality. Type I interferon (IFN) drives SLE pathology plasmacytoid dendritic cells (pDCs) are potent producers of IFN; however, the specific effects pDC depletion have not been demonstrated. We show CD123 was highly expressed on pDCs anti-CD123 antibody CSL362 potently depleted