A metagenome-wide association study of HIV disease progression in HIV controllers

• DOI: 10.1016/j.isci.2023.107214
• Publication Date: 2023-06-26T06:02:52Z
• Authors: Luis Miguel Real; María E. Sáez; Anais Corma-Gómez; Antonio Gonzalez-...; Christian Thorball; Rocío Ruiz; María Reyes Jimen...; Alejandro Gonzale...; Carmen Gasca-Capote; María José Bravo; José Luis Royo; Alberto Perez-Gomez; María Inés Camach...; Isabel Gallego; Joana Vitalle; Sara Bachiller; Alicia Gutierrez-...; Francisco Vidal; Jacques Fellay; Mathias Lichterfeld; Ezequiel Ruiz-Mateos
• Keywords: Genome-wide Association Study; SNP; Genetic Association

Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated lost in controllers. A total of 561 were included, 442 and 119 from the International Study Cohort Swiss Study, respectively. No SNP or gene was long-term non-progressor spontaneous control phenotype individual GWAS meta-analysis. However, SNPs previously natural linked HLA-B (rs2395029 [p = 0.005; OR 1.70], rs59440261 0.003; 1.78]), MICA (rs112243036 0.011; 1.45]), PSORS1C1 loci (rs3815087 0.017; 1.39]) showed nominal association this phenotype. Genetic without risk are those related overall controller